Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence.

• Main Authors: Fiona M Sansom (Author), Julie E Ralton (Author), M Fleur Sernee (Author), Alice M Cohen (Author), David J Hooker (Author), Elizabeth L Hartland (Author), Thomas Naderer (Author), Malcolm J McConville (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases) which hydrolyze a broad range of nucleoside tri- and diphosphates. However, the functional significance of NTPDases in parasite virulence is...