Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview
Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells. To develop non-surgical treatments, the molecular and cell...
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Frontiers Media S.A.,
2022-06-01T00:00:00Z.
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| 100 | 1 | 0 | |a Maria Bogdanova |e author |
| 700 | 1 | 0 | |a Arsenii Zabirnyk |e author |
| 700 | 1 | 0 | |a Arsenii Zabirnyk |e author |
| 700 | 1 | 0 | |a Anna Malashicheva |e author |
| 700 | 1 | 0 | |a Daria Semenova |e author |
| 700 | 1 | 0 | |a John-Peder Escobar Kvitting |e author |
| 700 | 1 | 0 | |a Mari-Liis Kaljusto |e author |
| 700 | 1 | 0 | |a Maria del Mar Perez |e author |
| 700 | 1 | 0 | |a Anna Kostareva |e author |
| 700 | 1 | 0 | |a Anna Kostareva |e author |
| 700 | 1 | 0 | |a Kåre-Olav Stensløkken |e author |
| 700 | 1 | 0 | |a Gareth J Sullivan |e author |
| 700 | 1 | 0 | |a Gareth J Sullivan |e author |
| 700 | 1 | 0 | |a Gareth J Sullivan |e author |
| 700 | 1 | 0 | |a Gareth J Sullivan |e author |
| 700 | 1 | 0 | |a Gareth J Sullivan |e author |
| 700 | 1 | 0 | |a Arkady Rutkovskiy |e author |
| 700 | 1 | 0 | |a Arkady Rutkovskiy |e author |
| 700 | 1 | 0 | |a Jarle Vaage |e author |
| 700 | 1 | 0 | |a Jarle Vaage |e author |
| 700 | 1 | 0 | |a Jarle Vaage |e author |
| 245 | 0 | 0 | |a Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview |
| 260 | |b Frontiers Media S.A., |c 2022-06-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.835825 | ||
| 520 | |a Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells. To develop non-surgical treatments, the molecular and cellular mechanisms of pathological calcification must be revealed. In the current overview, we present methods for evaluation of calcification in different ex vivo, in vitro and in vivo situations including imaging in patients. The latter include echocardiography, scanning with computed tomography and magnetic resonance imaging. Particular emphasis is on translational studies of calcific aortic valve stenosis with a special focus on cell culture using human primary cell cultures. Such models are widely used and suitable for screening of drugs against calcification. Animal models are presented, but there is no animal model that faithfully mimics human calcific aortic valve disease. A model of experimentally induced calcification in whole porcine aortic valve leaflets ex vivo is also included. Finally, miscellaneous methods and aspects of aortic valve calcification, such as, for instance, biomarkers are presented. | ||
| 546 | |a EN | ||
| 690 | |a aortic valve | ||
| 690 | |a interstitial cells | ||
| 690 | |a endothelial cells | ||
| 690 | |a calcification | ||
| 690 | |a animal models | ||
| 690 | |a calcified aortic valve disease | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.835825/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/bee968d2f14e495b851a83949d91c8bb |z Connect to this object online. |