Population Pharmacokinetic and Pharmacodynamic Analysis of Dalbavancin for Long-Term Treatment of Subacute and/or Chronic Infectious Diseases: The Major Role of Therapeutic Drug Monitoring

• Main Authors: Pier Giorgio Cojutti (Author), Sara Tedeschi (Author), Milo Gatti (Author), Eleonora Zamparini (Author), Marianna Meschiari (Author), Paola Della Siega (Author), Maria Mazzitelli (Author), Laura Soavi (Author), Raffaella Binazzi (Author), Elke Maria Erne (Author), Marco Rizzi (Author), Anna Maria Cattelan (Author), Carlo Tascini (Author), Cristina Mussini (Author), Pierluigi Viale (Author), Federico Pea (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A population pharmacokinetic analysis of dalbavancin was conducted in patients with different infection sites. Non-linear mixed effect modeling was used for pharmacokinetic analysis and covariate evaluation. Monte Carlo simulations assessed the probability of target attainment (PTA) of total dalbava...