Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

• Hauptverfasser: Tong Chen (Verfasst von), Jingbo Hu (Verfasst von), Huan Wang (Verfasst von), Nana Tan (Verfasst von), Jianzhao Qi (Verfasst von), Xiaoling Wang (Verfasst von), Le Wang (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2023-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Artemisiae Scopariae Herba (ASH) has been widely used as plant medicine in East Asia with remarkable antitumor activity. However, the underlying mechanisms have not been fully elucidated. Methods This study aimed to construct a multi-disciplinary approach to screen topoisomerase...