Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

Abstract Background Artemisiae Scopariae Herba (ASH) has been widely used as plant medicine in East Asia with remarkable antitumor activity. However, the underlying mechanisms have not been fully elucidated. Methods This study aimed to construct a multi-disciplinary approach to screen topoisomerase...

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Main Authors: Tong Chen (Author), Jingbo Hu (Author), Huan Wang (Author), Nana Tan (Author), Jianzhao Qi (Author), Xiaoling Wang (Author), Le Wang (Author)
Format: Book
Published: BMC, 2023-09-01T00:00:00Z.
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