Protein Fitness Prediction Is Impacted by the Interplay of Language Models, Ensemble Learning, and Sampling Methods

• Autori principali: Mehrsa Mardikoraem (Autore), Daniel Woldring (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Advances in machine learning (ML) and the availability of protein sequences via high-throughput sequencing techniques have transformed the ability to design novel diagnostic and therapeutic proteins. ML allows protein engineers to capture complex trends hidden within protein sequences that would oth...