The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX

• Main Authors: Zainab Saad Yusuf (Author), Tugba Kevser Uysal (Author), Ender Simsek (Author), Alessio Nocentini (Author), Sameh Mohamed Osman (Author), Claudiu T. Supuran (Author), Özen Özensoy Güler (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (EC 4.2.1.1) catalyse the reversible hydration of CO2 into bicarbonate and protons. As a hypoxia-sensitive and tumour-associated isoform, isoform CA IX, is significantly overexpressed in various malignancies, being a validated target for new anticancer/antimetastatic drugs. A mul...