The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX

• Päätekijät: Zainab Saad Yusuf (Tekijä), Tugba Kevser Uysal (Tekijä), Ender Simsek (Tekijä), Alessio Nocentini (Tekijä), Sameh Mohamed Osman (Tekijä), Claudiu T. Supuran (Tekijä), Özen Özensoy Güler (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Carbonic anhydrases (EC 4.2.1.1) catalyse the reversible hydration of CO2 into bicarbonate and protons. As a hypoxia-sensitive and tumour-associated isoform, isoform CA IX, is significantly overexpressed in various malignancies, being a validated target for new anticancer/antimetastatic drugs. A mul...