Unique epitope-antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display

• Main Authors: Feng Ni (Author), Cunle Wu (Author), Ping Xu (Author), Ping Wang (Author), Yves Fortin (Author), Melanie Arbour (Author), Luke Masson (Author), Denis L'Abbé (Author), Andrea Acel (Author), Mylene Gosselin (Author), Anne E.G. Lenferink (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTCarbonic anhydrase (CA)-IX is an extracellular enzyme that is essential in the adaptation of tumor cells to their increasingly more hypoxic and acidic microenvironment. Within the family of carbonic anhydrases, CA-IX is unique in that it is the only CA with an N-terminal intrinsically disord...