Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

• Main Authors: Liu Feng (Author), Wang Li (Author), Yu Chao (Author), Qin Huan (Author), Fang Lu (Author), Wang Yi (Author), Wang Jun (Author), Cui Binbin (Author), Liu Na (Author), Zhuang Shougang (Author)
• Format: Book
• Published: Karger Publishers, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they have a synergistic effect. Methods: In this s...