Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

• मुख्य लेखकों: Liu Feng (लेखक), Wang Li (लेखक), Yu Chao (लेखक), Qin Huan (लेखक), Fang Lu (लेखक), Wang Yi (लेखक), Wang Jun (लेखक), Cui Binbin (लेखक), Liu Na (लेखक), Zhuang Shougang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Karger Publishers, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they have a synergistic effect. Methods: In this s...