Lipidation of NOD2 Agonists with Adamantane and Stearoyl Moieties Differentially Regulates Their In Vivo Adjuvant Activity

• Ngā kaituhi matua: Samo Guzelj (Author), Marcela Šišić (Author), Špela Bizjak (Author), Leo Frkanec (Author), Ruža Frkanec (Author), Žiga Jakopin (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2022-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

NOD2 is an innate immune receptor that constitutes an important target for the development of small molecule immunopotentiators with great potential to be used as vaccine adjuvants. We report here the results of an in vivo study of the adjuvant properties of a desmuramylpeptide NOD2 agonist SG29 and...