Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

• Main Authors: Pieter C Steketee (Author), Isabel M Vincent (Author), Fiona Achcar (Author), Federica Giordani (Author), Dong-Hyun Kim (Author), Darren J Creek (Author), Yvonne Freund (Author), Robert Jacobs (Author), Kevin Rattigan (Author), David Horn (Author), Mark C Field (Author), Annette MacLeod (Author), Michael P Barrett (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addit...