Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

• Main Authors: Bumsoo Ahn (Author), Rojina Ranjit (Author), Pavithra Premkumar (Author), Gavin Pharaoh (Author), Katarzyna M. Piekarz (Author), Satoshi Matsuzaki (Author), Dennis R. Claflin (Author), Kaitlyn Riddle (Author), Jennifer Judge (Author), Shylesh Bhaskaran (Author), Kavithalakshmi Satara Natarajan (Author), Erika Barboza (Author), Benjamin Wronowski (Author), Michael Kinter (Author), Kenneth M. Humphries (Author), Timothy M. Griffin (Author), Willard M. Freeman (Author), Arlan Richardson (Author), Susan V. Brooks (Author), Holly Van Remmen (Author)
• Format: Book
• Published: Wiley, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology and function and muscle weakness has not been direct...