Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine?

• Váldodahkki: Marc H V Van Regenmortel (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: AIMS Press, 2015-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

It is commonly assumed that neutralizing Mabs that bind to the HIV-1 Env glycoprotein are more specific reagents than anti-HIV-1 polyclonal antisera and that knowledge of the structure of these Mabs facilitates the rational design of effective HIV-1 vaccine immunogens. However, after more than ten y...