USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway

• Autori principali: Fei Gao (Autore), Mingjiang Qian (Autore), Guoyue Liu (Autore), Wanping Ao (Autore), Dahua Dai (Autore), Cunzhi Yin (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathogenesis and treatment of acute kidney injury (AKI) is of great significance to reduce high mortality rate of sepsis. In this study, the mechan...