Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

• Main Authors: Amanda Fernandes de Medeiros (Author), Izael de Sousa Costa (Author), Fabiana Maria Coimbra de Carvalho (Author), Sumika Kiyota (Author), Beatriz Blenda Pinheiro de Souza (Author), Daniel Nogoceke Sifuentes (Author), Raphael Paschoal Serquiz (Author), Bruna Leal Lima Maciel (Author), Adriana Ferreira Uchôa (Author), Elizeu Antunes dos Santos (Author), Ana Heloneida de Araújo Morais (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...