Resveratrol Administration Increases Transthyretin Protein Levels, Ameliorating AD Features: The Importance of Transthyretin Tetrameric Stability

• Main Authors: Luís Miguel Santos (Author), Daniela Rodrigues (Author), Mobina Alemi (Author), Sara Costa Silva (Author), Carlos Alexandre Ribeiro (Author), Isabel Cardoso (Author)
• Format: Book
• Published: BMC, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer's disease (AD) pathology, resulting in increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding its aggregation and toxicity, and is reduced in the cerebrospinal fluid (C...