Loss of PTEN expression and AKT activation in HER2-positive breast carcinomas

• Main Authors: Francini de Mattos Lima Lin (Author), Carlos Eduardo Bacchi (Author), Edmund Chada Baracat (Author), Filomena Marino Carvalho (Author)
• Format: Book
• Published: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: To examine the expression of AKT and PTEN in a series of HER2-positive primary invasive breast tumors using immunohistochemistry, and to associate these expression profiles with classic pathologic features such as tumor grade, hormone receptor expression, lymphatic vascular invasion, and pr...