Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice

• Main Authors: Jing Zhao (Author), Ting Zhou (Author), Jing-Ze Lu (Author), Dan Ye (Author), Sheng Mu (Author), Xin-Hui Tian (Author), Wei-Dong Zhang (Author), Bing-Liang Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primary plant metabolites can be used for artificial preparation of natural deep eutectic solvents (NADESs), which have strong dissolving capacity, good biocompatibility, and biodegradability. In this study, for the first time, we verified that NADESs were present in Coptidis Rhizoma extract and sys...