Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in mice through the PI3K-Akt pathway

• Main Authors: Qin Liu (Author), Jinqiang Zhang (Author), Chenghong Xiao (Author), Dapeng Su (Author), Liangyuan Li (Author), Changgui Yang (Author), Zhihuang Zhao (Author), Weike Jiang (Author), Zili You (Author), Tao Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the ability of akebia saponin D (ASD) to protect various types of stem cells, in the present study, we hypothesized that ASD could promote the proliferation, differentiation, and survival of neural stem/precursor cells (NSPCs), even in a microglia-mediated inflammatory environment, thereby mit...