Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in mice through the PI3K-Akt pathway

• Prif Awduron: Qin Liu (Awdur), Jinqiang Zhang (Awdur), Chenghong Xiao (Awdur), Dapeng Su (Awdur), Liangyuan Li (Awdur), Changgui Yang (Awdur), Zhihuang Zhao (Awdur), Weike Jiang (Awdur), Zili You (Awdur), Tao Zhou (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Given the ability of akebia saponin D (ASD) to protect various types of stem cells, in the present study, we hypothesized that ASD could promote the proliferation, differentiation, and survival of neural stem/precursor cells (NSPCs), even in a microglia-mediated inflammatory environment, thereby mit...