Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties

• Main Authors: Rohmad Yudi Utomo (Author), Febri Wulandari (Author), Dhania Novitasari (Author), Beni Lestari (Author), Ratna Asmah Susidarti (Author), Riris Istighfari Jenie (Author), Jun-ya Kato (Author), Sardjiman Sardjiman (Author), Edy Meiyanto (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical and pharmacological properties.Methods: CCA-1.1 was prepared by changing the ketone group of PGV-1 into a hydroxyl...