Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes

• Main Authors: Chenshu Liu (Author), Na Li (Author), Meixiu Peng (Author), Kan Huang (Author), Dongxiao Fan (Author), Zhengde Zhao (Author), Xiuyi Huang (Author), Yunchong Liu (Author), Sifan Chen (Author), Zilun Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is one of the most prevalent chronic metabolic diseases, and induction of apoptosis in preadipocytes and adipocytes is a potential strategy to treat obesity. Celastrol represents one of the most robust anti-obesity phytochemicals so far, yet its direct binding target remains elusive. Here, w...