Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose, protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway

• Main Authors: Jun-Yu He (Author), Jie Li (Author), Yuan-Yuan Zhang (Author), Hai-Bo He (Author), Yu-Min He (Author), Dao-Xiang Xu (Author), Xiao Wang (Author), Hao-Yang Wu (Author), Ji-Hong Zhang (Author), Hasan Jahid (Author), Akter Sadia (Author), Hui-Fan Yu (Author), Jun-Zhi Wang (Author), Kun Zou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractContext Tormentic acid (TA), an effective triterpenoid isolated from Chaenomeles speciosa (Sweet) Nakai (Rosaceae) fruits, exerts an effective treatment for gastric damage.Objective To investigate the gastroprotective effect of TA on indomethacin (IND) damaged GES-1 cells and rats, and explo...