Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer

• Main Authors: Milene Volpato (Author), Michele Cummings (Author), Abeer M. Shaaban (Author), Balkees Abderrahman (Author), Mark A. Hull (Author), Philipp Y. Maximov (Author), Bradley M. Broom (Author), Reiner Hoppe (Author), Ping Fan (Author), Hiltrud Brauch (Author), V. Craig Jordan (Author), Valerie Speirs (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Tamoxifen (TAM) resistance remains a clinical issue in breast cancer. The authors previously reported that 15-hydroxyprostaglandin dehydrogenase (HPGD) was significantly downregulated in tamoxifen-resistant (TAMr) breast cancer cell lines. Here, the authors investigated the relationship between...