Characteristics of Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells

• Main Authors: Tomoko Aki (Author), Nobuaki Egashira (Author), Mika Hama (Author), Yui Yamauchi (Author), Takahisa Yano (Author), Yoshinori Itoh (Author), Ryozo Oishi (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gabexate mesilate (GM), a serine protease inhibitor, often causes severe vascular injury, when injected in high concentration. In the present study, we investigated the mechanisms for the cytotoxicity of GM on porcine aorta endothelial cells (PAECs). GM (0.5 -5.0 mM) decreased cell viability in a do...