Characteristics of Gabexate Mesilate-Induced Cell Injury in Porcine Aorta Endothelial Cells

• Egile Nagusiak: Tomoko Aki (Egilea), Nobuaki Egashira (Egilea), Mika Hama (Egilea), Yui Yamauchi (Egilea), Takahisa Yano (Egilea), Yoshinori Itoh (Egilea), Ryozo Oishi (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2008-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Gabexate mesilate (GM), a serine protease inhibitor, often causes severe vascular injury, when injected in high concentration. In the present study, we investigated the mechanisms for the cytotoxicity of GM on porcine aorta endothelial cells (PAECs). GM (0.5 -5.0 mM) decreased cell viability in a do...