Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane

• Main Authors: F. Ingegnoli (Author), M. Blades (Author), A. Manzo (Author), S. Wahid (Author), M. Perretti (Author), G. Panay (Author), C. Pitzalis (Author)
• Format: Book
• Published: PAGEPress Publications, 2002-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: adhesion mechanisms play a central role in the recruitment of leukocytes which characteristically infiltrate rheumatoid synovium. Therefore, we adapted an animal model, in which human rheumatoid synovium was transplanted into severe combined immunodeficient (SCID) mice, to study the effec...