The Effects of Synthetically Modified Natural Compounds on ABC Transporters

• Autori principali: Daniel Dantzic (Autore), Pawan Noel (Autore), Fabrice Merien (Autore), Dong-Xu Liu (Autore), Jun Lu (Autore), Haiyong Han (Autore), Mark J. McKeage (Autore), Yan Li (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2018-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumul...