The Effects of Synthetically Modified Natural Compounds on ABC Transporters

• Main Authors: Daniel Dantzic (Author), Pawan Noel (Author), Fabrice Merien (Author), Dong-Xu Liu (Author), Jun Lu (Author), Haiyong Han (Author), Mark J. McKeage (Author), Yan Li (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumul...