Drug Discovery for Overcoming Chronic Kidney Disease (CKD): New Therapy for CKD by a (Pro)Renin-Receptor-Blocking Decoy Peptide

• Main Authors: Atsuhiro Ichihara (Author), Mariyo Sakoda (Author), Asako Kurauchi-Mito (Author), Tatsuya Narita (Author), Kenichiro Kinouchi (Author), Hiroshi Itoh (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Discovery of the (pro)renin receptor uncovered a novel function of renin/prorenin as the receptor ligands in addition to the enzyme and its precursor. The bindings of renin and prorenin to the (pro)renin receptor trigger two major pathways: the angiotensin II-dependent pathway as a result of the enz...