Drug Discovery for Overcoming Chronic Kidney Disease (CKD): New Therapy for CKD by a (Pro)Renin-Receptor-Blocking Decoy Peptide

• Päätekijät: Atsuhiro Ichihara (Tekijä), Mariyo Sakoda (Tekijä), Asako Kurauchi-Mito (Tekijä), Tatsuya Narita (Tekijä), Kenichiro Kinouchi (Tekijä), Hiroshi Itoh (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2009-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Discovery of the (pro)renin receptor uncovered a novel function of renin/prorenin as the receptor ligands in addition to the enzyme and its precursor. The bindings of renin and prorenin to the (pro)renin receptor trigger two major pathways: the angiotensin II-dependent pathway as a result of the enz...