A whole‐body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies

• Main Authors: Wenbo Chen (Author), Britton Boras (Author), Tae Sung (Author), Wenyue Hu (Author), Mary E. Spilker (Author), David Z. D'Argenio (Author)
• 格式: 圖書
• 出版: Wiley, 2021-07-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract A circulatory model of granulopoiesis and its regulation is presented that includes neutrophil trafficking in the lungs, liver, spleen, bone marrow, lymph nodes, and blood. In each organ, neutrophils undergo transendothelial migration from vascular to interstitial space, clearance due to ap...