Physiologically based pharmacokinetic modeling of drug-drug interactions between ritonavir‐boosted atazanavir and rifampicin in pregnancy

• Hoofdauteurs: Shakir Atoyebi (Auteur), Maiara Camotti Montanha (Auteur), Ritah Nakijoba (Auteur), Catherine Orrell (Auteur), Henry Mugerwa (Auteur), Marco Siccardi (Auteur), Paolo Denti (Auteur), Catriona Waitt (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2024-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Ritonavir‐boosted atazanavir (ATV/r) and rifampicin are mainstays of second‐line antiretroviral and multiple anti‐TB regimens, respectively. Rifampicin induces CYP3A4, a major enzyme involved in atazanavir metabolism, causing a drug-drug interaction (DDI) which might be exaggerated in pregn...