Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.

• Asıl Yazarlar: Evan Craig (Yazar), Charles-Eugene Hu (Yazar), Chun Yu (Yazar), Emma L Handy (Yazar), Jason K Sello (Yazar), Peter E Kima (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LPV sizes and lower parasite numbers during experime...