Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.

• Principais autores: Evan Craig (Autor), Charles-Eugene Hu (Autor), Chun Yu (Autor), Emma L Handy (Autor), Jason K Sello (Autor), Peter E Kima (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LPV sizes and lower parasite numbers during experime...