Human Salivary Histatin-1 Attenuates Osteoarthritis through Promoting M1/M2 Macrophage Transition

• Main Authors: Antong Wu (Author), Janak Lal. Pathak (Author), Xingyang Li (Author), Wei Cao (Author), Wenchao Zhong (Author), Mingjing Zhu (Author), Qiuyu Wu (Author), Wanyi Chen (Author), Qiao Han (Author), Siqing Jiang (Author), Yuzhuo Hei (Author), Ziyi Zhang (Author), Gang Wu (Author), Qingbin Zhang (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is an inflammation-driven degenerative joint disease. Human salivary peptide histatin-1 (Hst1) shows pro-healing and immunomodulatory properties. but its role in OA treatment is not fully understood. In this study, we investigated the efficacy of Hst1 in the inflammation modulati...