Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

• Main Authors: Mark D Mathew (Author), Neal D Mathew (Author), Angela Miller (Author), Mike Simpson (Author), Vinci Au (Author), Stephanie Garland (Author), Marie Gestin (Author), Mark L Edgley (Author), Stephane Flibotte (Author), Aruna Balgi (Author), Jennifer Chiang (Author), Guri Giaever (Author), Pamela Dean (Author), Audrey Tung (Author), Michel Roberge (Author), Calvin Roskelley (Author), Tom Forge (Author), Corey Nislow (Author), Donald Moerman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lack of new anthelmintic agents is of growing concern because it affects human health and our food supply, as both livestock and plants are affected. Two principal factors contribute to this problem. First, nematode resistance to anthelmintic drugs is increasing worldwide and second, many effect...