Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial

• Main Authors: Diane E. Milenic (Author), Alfredo A. Molinolo (Author), María S. Solivella (Author), Eileen Banaga (Author), Julien Torgue (Author), Sarah Besnainou (Author), Martin W. Brechbiel (Author), Kwamena E. Baidoo (Author)
• Format: Book
• Published: MDPI AG, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concerns were expressed by the Food and Drug Administration (FDA) regarding 212Pb prematurely released from the mAb-chelate conjugate. The objective of this study was to simulate the worst case scenario of...