Structural Optimization of Platinum Drugs to Improve the Drug-Loading and Antitumor Efficacy of PLGA Nanoparticles

• Main Authors: Maria B. Sokol (Author), Margarita V. Chirkina (Author), Nikita G. Yabbarov (Author), Mariia R. Mollaeva (Author), Tatyana A. Podrugina (Author), Anna S. Pavlova (Author), Viktor V. Temnov (Author), Rania M. Hathout (Author), Abdelkader A. Metwally (Author), Elena D. Nikolskaya (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2022-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Currently, molecular dynamics simulation is being widely applied to predict drug-polymer interaction, and to optimize drug delivery systems. Our study describes a combination of in silico and in vitro approaches aimed at improvement in polymer-based nanoparticle design for cancer treatment. We appli...