Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice

• Main Authors: Hee-Hoon Kim (Author), Young-Ri Shim (Author), Sung Eun Choi (Author), Tolulope Esther Falana (Author), Jae-Kwang Yoo (Author), So-Hee Ahn (Author), Minhye Park (Author), Hyangmi Seo (Author), Chulhee Choi (Author), Won-Il Jeong (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) instigates nuclear factor-κB (NF-κB)-mediated inflammatory responses in alcohol-associated liver diseases (ALD). Here, we utilized a novel optogenetically engineered exosome technology called 'exosomes for protein loading...