Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

• Main Authors: Xiaolong Xu (Author), Hongquan Li (Author), Xiaolin Hou (Author), Deyin Li (Author), Shasha He (Author), Changrong Wan (Author), Peng Yin (Author), Mingjiang Liu (Author), Fenghua Liu (Author), Jianqin Xu (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reactive oxygen species (ROS) and oxidative stress are thought to play a central role in potentiating macrophage activation, causing excessive inflammation, tissue damage, and sepsis. Recently, we have shown that punicalagin (PUN) exhibits anti-inflammatory activity in LPS-stimulated macrophages. Ho...