Cinobufacini injection suppresses the proliferation of human osteosarcoma cells by inhibiting PIN1-YAP/TAZ signaling pathway

• Main Authors: Yuru Chen (Author), Yanyan Wang (Author), Yu Zhai (Author), Ye Yuan (Author), Junhong Wang (Author), Yajing Jin (Author), Lingling Dang (Author), Liming Song (Author), Changbao Chen (Author), Yu Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cinobufacini injection (CI), an aqueous extract of Cutis Bufonis, is clinically used for cancer therapy in China, but its molecular mechanism for the treatment of osteosarcoma (OS) remains unclear. We constructed U2OS ectopic subcutaneous tumor model to verify the anti-OS effect of CI in vivo. Meanw...