CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization

• Main Authors: Sook Hyun Chung (Author), Tzu-Ni Sin (Author), Brian Dang (Author), Taylor Ngo (Author), Therlinder Lo (Author), Daniella Lent-Schochet (Author), Ratheesh K. Meleppat (Author), Robert J. Zawadzki (Author), Glenn Yiu (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genomic disruption of vascular endothelial growth factor A (Vegfa) with a single gRNA suppresses choroidal neovascularization (CNV) in preclinical studies, offering the prospect of long-term anti-angiogenesis therapy for neovas...