Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats

• Main Authors: Nikita Hanning (Author), Michelle De bruyn (Author), Hannah Ceuleers (Author), Tim Boogaerts (Author), Maya Berg (Author), Annemieke Smet (Author), Heiko U. De Schepper (Author), Jurgen Joossens (Author), Alexander L. N. van Nuijs (Author), Joris G. De Man (Author), Koen Augustyns (Author), Ingrid De Meester (Author), Benedicte Y. De Winter (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of the protease-antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We aimed to study the potential therapeutic role of an in...