PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA

• Main Authors: Yingying Xu (Author), Yijing Zheng (Author), Xuqiu Ding (Author), Chengyan Wang (Author), Bin Hua (Author), Shilian Hong (Author), Xiaoman Huang (Author), Jiali Lin (Author), Peng Zhang (Author), Wei Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractInhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA delivery. Apart from the low pulmonary gene...