Efflux Pumps of Gram-negative bacteria: What they do, how they do it, with what and how to deal with them
This review discusses the relationship of the efflux pump system of Gram-negative bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing, biofilms, two component regulons, etc. The genetic responses of a Gram-negative to an antibiotic that render it immune to an a...
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| Main Authors: | , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2014-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | This review discusses the relationship of the efflux pump system of Gram-negative bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing, biofilms, two component regulons, etc. The genetic responses of a Gram-negative to an antibiotic that render it immune to an antibiotic are also discussed. Lastly, the methods that have been developed for the identification of bacteria that over-express their efflux pump system are presented in detail. Phenothiazines are well-known antipsychotic drugs with reported activity against bacterial efflux pumps and other ancillary antibiotic mechanisms of the organism. Therefore these compounds will also be discussed. |
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| Item Description: | 1663-9812 10.3389/fphar.2013.00168 |