The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326

• Main Authors: Brian E. Ford (Author), Shruti S. Chachra (Author), Katrina Rodgers (Author), Tabassum Moonira (Author), Ziad H. Al-Oanzi (Author), Quentin M. Anstee (Author), Helen L. Reeves (Author), Jörn M. Schattenberg (Author), Rebecca J. Fairclough (Author), David M. Smith (Author), Dina Tiniakos (Author), Loranne Agius (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associates with pleiotropic traits including lower Typ...