Application of RNAi to Genomic Drug Target Validation in Schistosomes.

• Main Authors: Alessandra Guidi (Author), Nuha R Mansour (Author), Ross A Paveley (Author), Ian M Carruthers (Author), Jérémy Besnard (Author), Andrew L Hopkins (Author), Ian H Gilbert (Author), Quentin D Bickle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in schistosomes offers great promise for the identi...