Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK has been implicated in tumorigenesis, cancer cell s...

Full description

Saved in:
Bibliographic Details
Main Authors: Michael E. Stokes (Author), Matthew D. Surman (Author), Veronica Calvo (Author), David Surguladze (Author), An-Hu Li (Author), Jennifer Gasparek (Author), Matthew Betzenhauser (Author), Guangyu Zhu (Author), Hongwen Du (Author), Alan C. Rigby (Author), Mark J. Mulvihill (Author)
Format: Book
Published: MDPI AG, 2022-10-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items