Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

• Главные авторы: Michael E. Stokes (Автор), Matthew D. Surman (Автор), Veronica Calvo (Автор), David Surguladze (Автор), An-Hu Li (Автор), Jennifer Gasparek (Автор), Matthew Betzenhauser (Автор), Guangyu Zhu (Автор), Hongwen Du (Автор), Alan C. Rigby (Автор), Mark J. Mulvihill (Автор)
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• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
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The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK has been implicated in tumorigenesis, cancer cell s...