Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK has been implicated in tumorigenesis, cancer cell s...
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MDPI AG,
2022-10-01T00:00:00Z.
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