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Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK has been implicated in tumorigenesis, cancer cell s...

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Main Authors:	Michael E. Stokes (Author), Matthew D. Surman (Author), Veronica Calvo (Author), David Surguladze (Author), An-Hu Li (Author), Jennifer Gasparek (Author), Matthew Betzenhauser (Author), Guangyu Zhu (Author), Hongwen Du (Author), Alan C. Rigby (Author), Mark J. Mulvihill (Author)
Format:	Book
Published:	MDPI AG, 2022-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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