St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood-brain barrier

• Main Authors: Myriam El Biali (Author), Michael Wölfl‐Duchek (Author), Matthias Jackwerth (Author), Severin Mairinger (Author), Maria Weber (Author), Karsten Bamminger (Author), Stefan Poschner (Author), Ivo Rausch (Author), Natalie Schindler (Author), Irene Hernández Lozano (Author), Walter Jäger (Author), Lukas Nics (Author), Nicolas Tournier (Author), Marcus Hacker (Author), Markus Zeitlinger (Author), Martin Bauer (Author), Oliver Langer (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract St. John's wort (SJW) extract, a herbal medicine with antidepressant effects, is a potent inducer of intestinal and/or hepatic cytochrome P450 (CYP) enzymes and P‐glycoprotein (P‐gp), which can cause clinically relevant drug interactions. It is currently not known whether SJW can also...