A phase I drug-drug interaction study to assess the effect of futibatinib on P‐gp and BCRP substrates and of P‐gp inhibition on the pharmacokinetics of futibatinib

• Main Authors: Amanda Long (Author), Ikuo Yamamiya (Author), Michelle Valentine (Author), Ziv Machnes (Author), Nanae Hangai (Author), Bailey Anderson (Author), Volker Wacheck (Author), Ling Gao (Author)
• Format: Knjiga
• Izdano: Wiley, 2024-09-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Futibatinib, an inhibitor of fibroblast growth factor receptor 1-4, is approved for the treatment of patients with advanced cholangiocarcinoma with FGFR2 fusions/rearrangements. In this phase I drug-drug interaction study, the effects of futibatinib on P‐glycoprotein (P‐gp) and breast cance...