Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury

• Main Authors: Jing-Bo Hu (Author), Gui-Ling Song (Author), Di Liu (Author), Shu-Juan Li (Author), Jia-Hui Wu (Author), Xu-Qi Kang (Author), Jing Qi (Author), Fei-Yang Jin (Author), Xiao-Juan Wang (Author), Xiao-Ling Xu (Author), Xiao-Ying Ying (Author), Lian Yu (Author), Jian You (Author), Yong-Zhong Du (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an attempt to improve therapeutic efficacy of dexamethasone (DXM)-loaded solid lipid nanoparticles (NPs) for renal ischemia-reperfusion injury (IRI)-induced acute renal injury (AKI), sialic acid (SA) is used as a ligand to target the inflamed vascular endothelium. DXM-loaded SA-conjugated polyeth...