Interventional cohort study of prolonged use (>72 hours) of paracetamol in neonates: protocol of the PARASHUTE study

• Main Authors: Sissel Sundell Haslund-Krog (Author), Steen Hertel (Author), Kim Dalhoff (Author), Susanne Poulsen (Author), Ulla Christensen (Author), Diana Wilkins (Author), John van den Anker (Author), Tine Brink Henriksen (Author), Helle Holst (Author)
• Format: Book
• Published: BMJ Publishing Group, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction Anticipated or actual pain in neonates results in use of paracetamol for prolonged pain relief in many neonatal intensive care units. Clinical trials examining safety of paracetamol exposure in neonates have been of short duration (1-3 days) and hepatic biomarkers and paracetamol metabo...